Indole-3-carboxylic acid is a tryptophan metabolite produced by microbiota in the human gut. Indole-3-carboxylic acid isolated from Streptomyces sp. is active against Gram positive bacteria, yeast and fungi. Indole-3-carboxylic acid induces resistance in Arabidopsis adult plants against the necrotrophic fungus Plectosphaerella cucumerina through primed callose accumulation. Indole-3-carboxylic acid is a useful skeleton for the design and synthesis of bioactive molecules.
| Molecular Formula | C9H7NO2 |
| References |
Kavitha A et al (2010) Purification and biological evaluation of the metabolites produced by Streptomyces sp. TK-VL_333. Res. Microbiol. 161:335 Liu T et al (2017) Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors. Bioorg. Med. Chem. 25: 1939 Liu T et al (2017) Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors. Bioorg.Med. Chem. 25: 1939 |
