Kijanimicin is a tetronic acid related to saccharocarcin, chlorothricin, versipelostatin and tetrocarcin. Like the tetrocarcins, kijanimicin contains an unusual nitroaminoglycoside. Kijanimicin is a potent antibacterial, antimalarial and antitumor active. Several members of this class have received considerable literature focus. Versipelostatin inhibits transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action is seen only in conditions of glucose deprivation and causes selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signalling pathway.
Kijanimicin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Kijanimicin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
| Molecular Formula | C67H100N2O24 |
| References | Kijanimicin (Sch 25663), a novel antibiotic produced by Actinomadura kijaniata SCC1256. Waitz, J.A. et al. , J. Antibiot., 1981, 34, 1101. Antitumor activity of kijanimicin Bradner W. T. J. Antibiot. 1983, 36, 1078. Effect on tumor cells of blocking survival response to glucose deprivation. Park H.R. J. Natl. Cancer. Inst. 2004, 96, 1300. Apoptosis and inactivation of the PI3-kinase pathway by tetrocarcin A in breast cancers. Nakajima H. Biochem Biophys Res Commun. 2007, 356, 260. |