Lateropyrone is an unusual heterocyclic metabolite isolated from Fusarium avenaceum with antibacterial and antifungal activity. The metabolite was independently characterised as Antibiotic Y and found to be an important metabolite marker for strains of F. avenaceum. Lack of availability has hitherto restricted a more intensive investigation of this metabolite.
Lateropyrone is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
Lateropyrone is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
| References | Pyrones. X. Lateropyrone, a new antibiotic from the fungus Fusarium lateritium Nees. Bushnell, G.W. et al. Can. J. Chem., 1984, 62, 2101. Structural elucidation of an antibiotic from Fusarium avenaceum Fries Sacc.; an amended structure for lateropyrone. Gorst-Allman, C.P. et al. , S. Afr. J. Chem., 1986, 39, 116. Multiple regression analysis as a tool for the identification of relations between semi-quantitative LC-MS data and cytotoxicity of extracts of the fungus Fusarium avenaceum (syn. F. arthrosporioides). Uhlig S. et al. Toxicon. 2006, 48, 567. |