Leptomycin A is an antifungal and methyl analog of leptomycin B, is a minor component of the Leptomycin complex produced by selected Streptomyces species. Leptomycin A, like Leptomycin B, is a potent inhibitor of the nuclear transport receptor exportin 1 (CRM1). The two may differ in exporter selectivity. Leptomycin A has antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus.
Leptomycin A is soluble in ethanol and methanol, practically insoluble in water, and unstable in DMSO.
|Mechanism of Action||
Leptomycin B inhibits CRM1, a nuclear export inhibitor. It inhibitors export of many RNAs (COX-2, cFOS mRNA).
Hamamoto T et al (1983) Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization.. J Antibiot. 36:639