SKU: L020  / 
    CAS Number: 87081-36-5

    Leptomycin A

    R$2,472.96 - R$8,641.92
    Leptomycin A

    Leptomycin A is an antifungal and methyl analog of Leptomycin B, is a minor component of the Leptomycin complex produced by selected Streptomyces species. Leptomycin A, like Leptomycin B, is a potent inhibitor of the nuclear transport receptor exportin 1 (CRM1). The two may differ in exporter selectivity.  The compound is less potent than its analog, Leptomycin B.  Leptomycin A has antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus. 

    Leptomycin A is soluble in ethanol and methanol, practically insoluble in water, and unstable in DMSO.

    We also offer:

    • Leptomycin B (L004)
    • Kazusamycin A (K018)
    • Kazusamycin B (K019)
    Mechanism of Action Leptomycin A inhibits CRM1 (exportin 1), a nuclear export inhibitor, preventing the nuclear export of a broad range of proteins.  It suppresses HIV-1 replication.  
    References

    Hamamoto T et al (1983)  Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization.. J Antibiot. 36:639

    Hamamoto T et al (1983)  Leptomycins A and B, new antifungal antibiotics. II. Structure elucidation. J Antibiot. 36:646

    Wang Y et al (2004)  Novel leptomycins from a Streptomyces strain A92-308902: Inhibitors of the nucleo-cytoplasmic translocation of the HIV-1 regulatory protein Rev.  Helvetica 80(7):2157-2167