Linearmycin A is novel linear polyene antibiotic isolated from mycelial extracts of Streptomyces sp. Linearmycin A and B have similar, long linear structures terminating with amino and carboxylic acid groups. The carboxylic acid terminal of linearmycin A links to a tetraenone, whereas linearmycin B links to a pentaenone. Linearmycin A has antifungal activity against Candida albicans. Linearmycin A has antibacterial activity, causing cellular lysis and colony degradation of the Gram-positive bacterium Bacillus subtilis acting directly on the cytoplasmic membrane.
| Molecular Formula | C64H101NO16 |
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Sakuda et al (1995) Linearmycin A, a novel linear polyene antibiotic. Tetrahed. Lett. 36:2777 Sakuda S et al (1996) Novel linear polyene antibiotics: linearmycins. J. Chem. Soc. Perkin Trans. 1:2315 Stubbendieck RM et al (2018) Linearmycins are lytic membrane-targeting antibiotics. J. Antibiot. 71:372 |