SKU: L057  / 
    CAS Number: 163596-98-3

    Linearmycin A

    $225,207.58 - $786,748.78

    Linearmycin A is novel linear polyene antibiotic isolated from mycelial extracts of Streptomyces sp. Linearmycin A and B have similar, long linear structures terminating with amino and carboxylic acid groups. The carboxylic acid terminal of linearmycin A links to a tetraenone, whereas linearmycin B links to a pentaenone. Linearmycin A has antifungal activity against Candida albicans. Linearmycin A has antibacterial activity, causing cellular lysis and colony degradation of the Gram-positive bacterium Bacillus subtilis acting directly on the cytoplasmic membrane.

    Molecular Formula  C64H101NO16
     

    Sakuda et al (1995)  Linearmycin A, a novel linear polyene antibiotic. Tetrahed. Lett. 36:2777

    Sakuda S et al (1996)  Novel linear polyene antibiotics: linearmycins.  J. Chem. Soc. Perkin Trans. 1:2315

    Stubbendieck RM et al (2018)  Linearmycins are lytic membrane-targeting antibiotics. J. Antibiot. 71:372