SKU: L046  / 
    CAS Number: 597562-32-8

    LL-37 (human) trifluoroacetate salt

    LL-37 is a naturally-occuring antimicrobial peptide that is part of the innate host immune system. It is associated with the epidermis and protects the host from bacterial infection. LL-37 has also demonstrated a range of other bioactivity including anti-influenza, immunomodulatory, and cell death activity in certain cell types. Unlike other antimicrobial peptides, LL-37 can aggregate to protect from proteolytic degredation.
    Mechanism of ActionLL-37 assumes a primarily α-helical shape during membrane interactions allowing for membrane penetration, formation of transmembrane pores and bacterial lysis.
    Molecular FormulaC205H340N60O53
    ReferencesKahlenberg, J. M., & Kaplan, M. J. (2013). Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease. The Journal of Immunology, 191(10), 4895-4901. doi:10.4049/jimmunol.1302005