LL-37 is a naturally-occuring antimicrobial peptide that is part of the innate host immune system. It is associated with the epidermis and protects the host from bacterial infection. LL-37 has also demonstrated a range of other bioactivity including anti-influenza, immunomodulatory, and cell death activity in certain cell types. Unlike other antimicrobial peptides, LL-37 can aggregate to protect from proteolytic degredation.
|Mechanism of Action||LL-37 assumes a primarily α-helical shape during membrane interactions allowing for membrane penetration, formation of transmembrane pores and bacterial lysis.|
|References||Kahlenberg, J. M., & Kaplan, M. J. (2013). Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease. The Journal of Immunology, 191(10), 4895-4901. doi:10.4049/jimmunol.1302005|