SKU: L059  / 
    CAS Number: 550-90-3

    Lupanine

    $192.50 - $673.50

    Lupanine is a tetracyclic quinolizidine isolated from lupins. Lupanine inhibits the growth of phytopathogenic fungi, reducing the germination of conidia of powdery mildew and the further development to appressoria with an IC50 of 1-5 mmol/L. Lupanine inhibits the germination of Lactuca sativa L. In animal models of Type 2 diabetes, lupanine modulates insulin release via inhibition of ATP-dependent K+ channels and increases the expression of the Ins-1 gene. Lupin seed extracts containing Lupanine have anthelmintic activity, inhibiting the migration of susceptible and multidrug resistant Haemonchus contortus and susceptibe Teladorsagia circumcincta. Lupin extracts are active against Gram-positive and Gram-negative bacteria.

    Molecular Formula  C15H24N2O
    References

    Clemo GR and Leitch GC (1928) XXXII.—The lupin alkaloids. Part I. G.C. J. Chem. Soc. 1811

    Dubois O et al (2019)  Lupin (Lupinus spp.) seeds exert anthelmintic activity associated with their alkaloid content. Sci. Rep. 9:9070

    Kucukboyaci N et al (2007)  Alkaloid profile and antimicrobial activity of Lupinus angustifolius L. alkaloid extract. Phytochem. Rev. 6:197

    Wink M (1983)  Inhibition of seed germination by quinolizidine alkaloids. Planta 158:365

    Wippich C and Wink M (1985)  Biological properties of alkaloids. Influence of quinolizidine alkaloids and gramine on the germination and development of powdery mildew, Erysiphe graminis Lsp. Hordei. Experientia 41:1477