SKU: L059  / 
    CAS Number: 550-90-3

    Lupanine

    $119,812.29 - $417,560.91
    • Detailed Description

      CAS Number: 550-90-3

      Molecular Formula: C15H24N2O

      Molecular Weight: 248.4

      Tariff Code: 3822.00.5090

    • Specifications

      Form: Solid

      Appearance: Off-white solid

      Source: Lupinus albus L.

    • Technical Data

      Solubility: Soluble in methanol or DMSO

    • References

      References:

      Clemo GR and Leitch GC (1928) XXXII.—The lupin alkaloids. Part I. G.C. J. Chem. Soc. 1811

      Dubois O et al (2019)  Lupin (Lupinus spp.) seeds exert anthelmintic activity associated with their alkaloid content. Sci. Rep. 9:9070

      Kucukboyaci N et al (2007)  Alkaloid profile and antimicrobial activity of Lupinus angustifolius L. alkaloid extract. Phytochem. Rev. 6:197

      Wink M (1983)  Inhibition of seed germination by quinolizidine alkaloids. Planta 158:365

      Wippich C and Wink M (1985)  Biological properties of alkaloids. Influence of quinolizidine alkaloids and gramine on the germination and development of powdery mildew, Erysiphe graminis Lsp. Hordei. Experientia 41:1477

       

    Lupanine is a tetracyclic quinolizidine isolated from lupins. Lupanine inhibits the growth of phytopathogenic fungi, reducing the germination of conidia of powdery mildew and the further development to appressoria with an IC50 of 1-5 mmol/L. Lupanine inhibits the germination of Lactuca sativa L. In animal models of Type 2 diabetes, lupanine modulates insulin release via inhibition of ATP-dependent K+ channels and increases the expression of the Ins-1 gene. Lupin seed extracts containing Lupanine have anthelmintic activity, inhibiting the migration of susceptible and multidrug resistant Haemonchus contortus and susceptibe Teladorsagia circumcincta. Lupin extracts are active against Gram-positive and Gram-negative bacteria.

     

    CAS Number: 550-90-3

    Molecular Formula: C15H24N2O

    Molecular Weight: 248.4

    Tariff Code: 3822.00.5090

    Form: Solid

    Appearance: Off-white solid

    Source: Lupinus albus L.

    Solubility: Soluble in methanol or DMSO

    References:

    Clemo GR and Leitch GC (1928) XXXII.—The lupin alkaloids. Part I. G.C. J. Chem. Soc. 1811

    Dubois O et al (2019)  Lupin (Lupinus spp.) seeds exert anthelmintic activity associated with their alkaloid content. Sci. Rep. 9:9070

    Kucukboyaci N et al (2007)  Alkaloid profile and antimicrobial activity of Lupinus angustifolius L. alkaloid extract. Phytochem. Rev. 6:197

    Wink M (1983)  Inhibition of seed germination by quinolizidine alkaloids. Planta 158:365

    Wippich C and Wink M (1985)  Biological properties of alkaloids. Influence of quinolizidine alkaloids and gramine on the germination and development of powdery mildew, Erysiphe graminis Lsp. Hordei. Experientia 41:1477