SKU: L041  / 
    CAS Number: 75580-37-9

    Luzopeptin A

    $299.95 - $1,049.83
    Luzopeptin A is a member of the echinomycin (quinomycin A) class of antitumor and antibiotic agents. Luzopeptin A is also a potent inhibitor of HIV-1 reverse transcriptase.

    Luzopeptin A is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
    Mechanism of ActionLuzopeptin A acts by forming a stable DNA complex by bis-intercalation.
    ReferencesBBM-928, a new antitumor antibiotic complex I. Production, isolation, characterization and antitumor activity. Ohkuma, H. et al. , J. Antibiot. 1980, 33, 1087.

    Screening for inhibitors of avian myeloblastosis virus reverse transcriptase and effect on the replication of AIDS virus. Inouye Y.J. Antibiot. 1987, 40, 100.

    Proton exchange in DNA-luzopeptin and DNA-echinomycin bisintercalation complexes: rates and processes of base-pair opening. Leroy J.L. et al. Biochemistry. 1992, 31, 1407.