Luzopeptin A is a member of the echinomycin (quinomycin A) class of antitumor and antibiotic agents. Luzopeptin A is also a potent inhibitor of HIV-1 reverse transcriptase.
Luzopeptin A is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
Luzopeptin A is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
| Mechanism of Action | Luzopeptin A acts by forming a stable DNA complex by bis-intercalation. |
| References | BBM-928, a new antitumor antibiotic complex I. Production, isolation, characterization and antitumor activity. Ohkuma, H. et al. , J. Antibiot. 1980, 33, 1087. Screening for inhibitors of avian myeloblastosis virus reverse transcriptase and effect on the replication of AIDS virus. Inouye Y.J. Antibiot. 1987, 40, 100. Proton exchange in DNA-luzopeptin and DNA-echinomycin bisintercalation complexes: rates and processes of base-pair opening. Leroy J.L. et al. Biochemistry. 1992, 31, 1407. |
