SKU: L041  / 
    CAS Number: 75580-37-9

    Luzopeptin A

    $205,110.31 - $711,679.58
    Luzopeptin A

    Luzopeptin A is a member of the echinomycin (quinomycin A) class of antitumor and antibiotic agents. Luzopeptin A is also a potent inhibitor of HIV-1 and HIV-2 reverse transcriptase.  

    Luzopeptin A is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.

    Mechanism of Action Luzopeptin A acts by forming a stable DNA complex by bis-intercalation.
    References

    Inouye YJ et al (1987)  Screening for inhibitors of avian myeloblastosis virus reverse transcriptase and effect on the replication of AIDS virus. 40:100

    Leroy JL et al (1992)  Proton exchange in DNA-luzopeptin and DNA-echinomycin bisintercalation complexes: rates and processes of base-pair opening. Biochemistry. 31:1407

    Ohkuma H et al (1980)  BBM-928, a new antitumor antibiotic complex I. Production, isolation, characterization and antitumor activity. J. Antibiot. 33:1087