Lydicamycin belongs to a novel structural class with highly selective antibiotic activity. Recent research has shown that Lydicamycin and the related metabolites, TPU-0037A and TPU-0037C, are highly active against MRSA. Lydicamycin is also closely related to BN 4515N which was isolated from a strain of Microtetraspora as a neuritogenic agent.
Lydicamycin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
| Molecular Formula | C47H74N4O10 |
| References | TPU-0037-A, B, C and D, novel lydicamycin congeners with anti-MRSA activity from Streptomyces platensis TP-A0598. Furumai T. et al. J. Antibiot. 2002, 55, 873. A new neuritogenetic compound BU-4514N produced by Microtetraspora sp.. Toda S. et al. J Antibiot. 1993, 46, 875. Lydicamycin, a new antibiotic of a novel skeletal type. I. Taxonomy, fermentation, isolation and biological activity. Hayakawa Y. et al. J Antibiot. 1991, 44, 282. Lydicamycin, a new antibiotic of a novel skeletal type. II. Physico-chemical properties and structure elucidation. Hayakawa Y. et al. J Antibiot. 1991, 44, 288. |