SKU: M074  / 
    CAS Number: 108433-95-0

    Magainin II

    $210.25
    Magainin II is an antimicrobial peptide originally isolated from Xenopus laevis, with excellent antibiotic activity across a broad-spectrum. It has also demonstrated antifungal activity in vitro and anticancer activity in vitro and in a mouse model.

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    Mechanism of ActionMagainin II is believed to form pores in the target bacterial membrane, causing lysis and death.
    Molecular FormulaC114H180N30O29S
    ReferencesImura, Y., Choda, N., & Matsuzaki, K. (2008). Magainin 2 in Action: Distinct Modes of Membrane Permeabilization in Living Bacterial and Mammalian Cells. Biophysical Journal, 95(12), 5757-5765. doi:10.1529/biophysj.108.133488

    Lehmann, J., Retz, M., Sidhu, S. S., Suttmann, H., Sell, M., Paulsen, F., . . . Stöckle, M. (2006). Antitumor Activity of the Antimicrobial Peptide Magainin II against Bladder Cancer Cell Lines. European Urology, 50(1), 141-147. doi:10.1016/j.eururo.2005.12.043

    Zasloff, M. (1988). Magainins, a class of antimicrobial peptides from Xenopus skin: Isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Journal of Ethnopharmacology, 23(2-3), 360. doi:10.1016/0378-8741(88)90095-5