Magainin II is an antimicrobial peptide originally isolated from Xenopus laevis, with excellent antibiotic activity across a broad-spectrum. It has also demonstrated antifungal activity in vitro and anticancer activity in vitro and in a mouse model.
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| Mechanism of Action | Magainin II is believed to form pores in the target bacterial membrane, causing lysis and death. |
| Molecular Formula | C114H180N30O29S |
| References | Imura, Y., Choda, N., & Matsuzaki, K. (2008). Magainin 2 in Action: Distinct Modes of Membrane Permeabilization in Living Bacterial and Mammalian Cells. Biophysical Journal, 95(12), 5757-5765. doi:10.1529/biophysj.108.133488 Lehmann, J., Retz, M., Sidhu, S. S., Suttmann, H., Sell, M., Paulsen, F., . . . Stöckle, M. (2006). Antitumor Activity of the Antimicrobial Peptide Magainin II against Bladder Cancer Cell Lines. European Urology, 50(1), 141-147. doi:10.1016/j.eururo.2005.12.043 Zasloff, M. (1988). Magainins, a class of antimicrobial peptides from Xenopus skin: Isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Journal of Ethnopharmacology, 23(2-3), 360. doi:10.1016/0378-8741(88)90095-5 |
