SKU: M110  / 
    CAS Number: 52665-74-4

    Manumycin A

    $185.22 - $648.27

    Manumycin A was isolated by Zeeck and colleagues at the University of Gottingen, Germany published in 1987. Manumycin A is a potent and selective inhibitor of Ras farnesyl transferase. Manumycin A induces apoptosis and inhibits angiogenesis, and has antibacterial, anti-inflammatory and antiparasitic activity. Manumycin A retards the development of atherosclerosis with concomitant alleviation of oxidative stress in apoE-deficient mice.

    Molecular Formula  C31H38N2O7  
    References

    Hara M et al (1993)  Identification of Ras farnesyltransferase inhibitors by microbial screening 90:2281

    Sharma V et al (2012)  Farnesyltransferase inhibitor manumycin targets IL1β-Ras-HIF-1α axis in tumor cells of diverse origin. Inflamm. 35:516

    Sugita M et al (2007)  Farnesyltransferase inhibitor, manumycin a, prevents atherosclerosis development and reduces oxidative stress in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 27:1390

    Zeeck A et al (1987)  The structure of Manumycin. I. Characterization, structure elucidation and biological activity. 40:1530