Manumycin A was isolated by Zeeck and colleagues at the University of Gottingen, Germany published in 1987. Manumycin A is a potent and selective inhibitor of Ras farnesyl transferase. Manumycin A induces apoptosis and inhibits angiogenesis, and has antibacterial, anti-inflammatory and antiparasitic activity. Manumycin A retards the development of atherosclerosis with concomitant alleviation of oxidative stress in apoE-deficient mice.
| Molecular Formula | C31H38N2O7 |
| References | Hara M et al (1993) Identification of Ras farnesyltransferase inhibitors by microbial screening 90:2281 Sharma V et al (2012) Farnesyltransferase inhibitor manumycin targets IL1β-Ras-HIF-1α axis in tumor cells of diverse origin. Inflamm. 35:516 Sugita M et al (2007) Farnesyltransferase inhibitor, manumycin a, prevents atherosclerosis development and reduces oxidative stress in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 27:1390 Zeeck A et al (1987) The structure of Manumycin. I. Characterization, structure elucidation and biological activity. 40:1530 |