SKU: M014  / 
    CAS Number: 115550-35-1

    Marbofloxacin

    $151.37 - $393.61

    Marbofloxacin is broad-spectrum, third-generation fluoroquinolone antibiotic and is freely soluble in aqueous solution.  It is commonly used in studying antimicrobial resistance and antimicrobial susceptibility testing.

    Mechanism of ActionFluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. DNA gyrase is required during DNA replication, thus causes an inhibition of DNA synthesis and cell division..
    SpectrumMarbofloxacin is a broad-spectrum antibiotic active against Gram-positive and Gram-negative bacteiria including Pseudomonas and Staphylococci species. It is also active against Mycoplasma.
    Impurity ProfileImpurity A| 6,7-difluoro-8-hydroxy-1-(methylamino)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity B| 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[3,2,1-ij][4,1,2]benzoxadiazine-6-carboxylic acid|||| Impurity C| 6,8-difluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity D| 6-fluoro-8-hydroxy-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity E| 8-ethoxy-6-fluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity F| 4-[6-carboxy-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[3,2,1-ij][4,1,2]benzoxadiazin-10-yl]-1-methylpiperazine 1-oxide||||
    Microbiology Applications

    Marbofloxacin is commonly used for in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. 
    Representative MIC values include:

    • Pseudomonas aeruginosa 0.5 µg/mL
    • Staphylococcus aureus 0.25 µg/mL

    For a representative list of Marbofloxacin MIC values, click here.

    The in vitro activity of Marbofloxacin, a quinolone, was evaluated on 124 anaerobic human strains isolated from the gut and  testing revealed that Marbofloxacin was similalr or superior to Ofloxacin for the whole anaerobes such as Enterococcus, Enterobacteriaceae, and Lactobacillus  (Dubreuil  et al, 1996). 



    Molecular FormulaC17H19FN4O4
    References

    Dubreuil L, Houcke I and Leroy I (1996)  In vitro activity of a new fluoroquinolone, marbofloxacin (RO 09-1168) against strictly anaerobic bacteria and some bacteria from human fecal flora.   Pathol-biol. 44(5):333-336  PMID 8758470

    Spring M, Deleforge J, Thomas V, Boisrme B and Drugeon H (1995)  Antibacterial activity of marbofloxacin. A new fluoroquinolone for veterinary use against canine and feline isolates. J. Vet. Pharmacol and Ther. 18(4):284-289  PMID 8583541

    Wolfson, JS and David C. Hooper DC (1985)  The Fluoroquinolones: Structures, mechanisms of action and resistance, and spectra of activity in vitro  Antimicrob. Agents. Chemother. 28: 581-586  PMID  3000292

    MICEscherichia coli| 0.0115 - 64|| Pseudomonas aeruginosa| 0.5|| Staphylococcus aureus| 0.25 - 64|| Staphylococcus epidermidis| 0.5|| Staphylococcus intermedius| 0.25 - 1|| Staphylococcus warneri| 0.25 - 0.5|| Streptococcus canis| 1||