Menadione Sodium Bisulfite (syn: Vitamin K3) is the metabolic precursor to Vitamin K2 in mammals. It belongs to the class 1,4-naphthoquinones, specifically a 1,4-naphthoquinone, which is substituted at position 2 by a methyl group. It is a possible anticancer agent, causing induction of apoptosis. It can inhibit angiogenesis, inhibit EC 3.4.22.69 (SARS coronavirus proteinase). Menadione is a potent inhibitor of aldehyde oxidase. It is an antifibrinolytic agent (an agent that can prevent lysis of a blood clot). Vitamin K3 is a synthetic compound that is converted to its active form (Vitamin K2) inside the body.
Menadione Sodium Bisulfite is soluble in aqueous solution.
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- Menadione (M079)
| Mechanism of Action | Menadione is a cofactor in the gamma-carboxylation of glutamic acid residues of certain proteins. The proteins are vitamin K-dependent coagulation factors. |
| References | Hirota Y et al (2013) Menadione (Vitamin K3) Is a catabolic product of oral phylloquinone (Vitamin K1) in the intestine and a circulating precursor of tissue Menaquinone-4 (Vitamin K2) in Rats. J. Biol. Chem. 288(46): 33071-33080 Suresh S, Raghu D, and Karunagaran D (2013) Menadione (Vitamin K3) induces apoptosis of human oral cancer cells and reduces their metastatic potential by modulating the expression of epithelial to mesenchymal transition markers and inhibiting migration. Asian Pac. J. Cancer Prev.14(9):5461-5465 |
| Cancer Applications | Menadione is a possible anticancer agent, causing induction of apoptosis (Suresh et al, 2013). |
