SKU: M113  / 
    CAS Number: 808750-39-2

    Mensacarcin

    ¥47,422.49 - ¥157,924.79

    Mensarcarcin is an unusual anthracene metabolite of Streptomyces sp. containing nine stereogenic centres and two epoxy functionalities first isolated by Zeeck and co-workers in the late 1990s. Mensacarcin has broad antitumor activity. Mensacarcin activates caspase-​3​/7-​dependent apoptotic pathways and induces cell death in SK-​Mel-​28 and SK-​Mel-​5 melanoma cells with the BRAF(V600E) mutation associated with drug resistance, showing characteristic chromatin condensation as well as poly(ADP-​ribose)​polymerase-​1 cleavage. The epoxy moieties are primarily responsible for the cytotoxic effect of mensocarcin.

    Molecular Formula  C21H24O9
    References

    Maier S et al (2014)  Insights into the bioactivity of Mensacarcin and epoxide formation by MsnO8. Chem. Bio. Chem. 15:749

    Plitzko B et al (2017)  The natural product Mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells. J. Biol. Chem. 292:21102

    Tietze L et al (2004)  Towards a total synthesis of the new anticancer agent Mensacarcin: Synthesis of the carbocyclic core. Chemistry 10:5233