Mizoribine is an imidazole nucleoside which acts as an immunosuppressant by inhibiting lymphocyte proliferation. Mizoribine is freely soluble in water (20 mg/mL).
| Mechanism of Action | Mizoribine inhibits inosine monophosphate synthetase and guanosine monophosphate synthetase which halts guanine synthesis and ultimately, DNA synthesis. |
| Molecular Formula | C9H13N3O6 |
| References | Yokota, Shumpei. "Mizoribine: Mode of Action and Effects in Clinical Use." Pediatrics International 44.2 (2002): 196-98. Onlinelibrary.com. Web. 25 June 2013. Mitoshirocho, Kanda. "Mizoribine and Mycophenolate Mofetil." Current Medicinal Chemistry 6 (1999): 575-97. Ncbi.gov. Web. 25 June 2013. |