Moenomycin complex is a mixture of five major components, A, A12, C1, C3 and C4, isolated from several strains of Streptomyces in the 1960s. Moenomycins are high molecular weight phosphoglycolipids with potent antibiotic activity used in animal health.
Moenomycin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Moenomycin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
| Mechanism of Action | Moenomycins are the only antibiotic known to selectively inhibit the transglycosylation step catalysed by penicillin-binding protein 1b. |
| Molecular Formula | C69H107N4O35P (for A) |
| References | Moenomycin, a new antibiotic. II. Characterization and chemistry. Huber G. et al. Antimicrob. Agents Chemother. 1965, 5, 737. Membrane intermediates in the peptidoglycan metabolism of Escherichia coli: Possible roles of PBP 1b and PBP 3. Van Heijenoort Y. et al. J. Bacteriol. 1992, 174, 3549. |