Monazomycin is a macrocylic polyol lactone isolated from several species of Streptoverticillium, first reported in 1963. Monazomycin is active against Gram positive bacteria with weak Gram negative activity. Monazomycin is an important bioprobe for understanding membrane channels.
Monazomycin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Monazomycin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
| Mechanism of Action | In solution, monazomycin exists as hydrophilic clusters which, when adsorbed onto a lipid bilayer, can induce channel formation. |