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Detailed Description
CAS Number: 22373-78-0
Molecular Formula: C36H61NaO11
Molecular Weight: 692.85
Mechanism of Action: As an ionophore, Monensin can disrupt the natural ion gradients such as Ca2+, Mg2+, K+ and Na+, and affect transmembrane ion transport.
Storage Conditions: 2-8°C
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Applications
Eukaryotic Cell Culture Applications: Liver microsomes were used to study the P-450 isoenzymes involved in the biotransformation of the ionophore Monensin and how it may be affected by chemotherapeutic agents. Results suggest that P-450 3A can play an important role in the oxidative metabolism of Monensin (Nebbia et al, 1999).
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Specifications
Source: Streptomyces cinnamonensis
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Technical Data
Solubility: Soluble in chloroform, methanol, and other organic solvents. Slightly soluble in water.
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References
References:
Aowicki D and Huczyński A (2013) Structure and antimicrobial properties of Monensin A and its derivatives: Summary of the achievements. Biomed Res Int. 2013:742149 PMID 23509771
Agtarap A, Chamberlin JW, Pinkerton M, Steinrauf L. (1967) The structure of Monensic acid, a new biologically active compound. J Am Chem Soc. 89(22):5737-5739 PMID 5622366
Butaye, P, Devriese LA and Haesebrouck F (2003) Antimicrobial growth promoters used in animal feed: Effects of less well known antibiotics on Gram-positive bacteria. Clin. Microbiol. Rev. 16(2): 175–188
Griffiths G, Quinn P, Warren G (1983) Dissection of the Golgi complex. I. Monensin inhibits the transport of viral membrane proteins from medial to trans Golgi cisternae in baby hamster kidney cells infected with Semliki Forest virus. J Cell Biol. 1983 Mar;96(3):835-50. PMID 6682112
Lowicki, D and Huczyński A (2013). Structure and antimicrobial properties of Monensin A and its derivatives: Summary of the achievements. BioMed Res. Intl. 1–14. doi:10.1155/2013/742149
Nebbia C, Ceppa L, Dacasto M, Carletti M, Nachtmann C (1999) Oxidative metabolism of Monensin in rat liver microsomes and interactions with tiamulin and other chemotherapeutic agents: Evidence for the involvement of cytochrome P-450 3A subfamily. Drug Metab Dispos. 1999 Sep;27(9):1039-44 PMID 10460804
Monensin Sodium, USP is a naturally occurring ionophore, used as a nonhormonal growth promoter and coccidiostat. It is a polyether antibiotic used against Gram-negative bacteria and has antiparasitic activity.
Monensin Sodium is soluble in chloroform, methanol, and other organic solvents and slightly soluble in water.
This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for questions.
CAS Number: 22373-78-0
Molecular Formula: C36H61NaO11
Molecular Weight: 692.85
Mechanism of Action: As an ionophore, Monensin can disrupt the natural ion gradients such as Ca2+, Mg2+, K+ and Na+, and affect transmembrane ion transport.
Storage Conditions: 2-8°C
Eukaryotic Cell Culture Applications: Liver microsomes were used to study the P-450 isoenzymes involved in the biotransformation of the ionophore Monensin and how it may be affected by chemotherapeutic agents. Results suggest that P-450 3A can play an important role in the oxidative metabolism of Monensin (Nebbia et al, 1999).
Source: Streptomyces cinnamonensis
Solubility: Soluble in chloroform, methanol, and other organic solvents. Slightly soluble in water.
References:
Aowicki D and Huczyński A (2013) Structure and antimicrobial properties of Monensin A and its derivatives: Summary of the achievements. Biomed Res Int. 2013:742149 PMID 23509771
Agtarap A, Chamberlin JW, Pinkerton M, Steinrauf L. (1967) The structure of Monensic acid, a new biologically active compound. J Am Chem Soc. 89(22):5737-5739 PMID 5622366
Butaye, P, Devriese LA and Haesebrouck F (2003) Antimicrobial growth promoters used in animal feed: Effects of less well known antibiotics on Gram-positive bacteria. Clin. Microbiol. Rev. 16(2): 175–188
Griffiths G, Quinn P, Warren G (1983) Dissection of the Golgi complex. I. Monensin inhibits the transport of viral membrane proteins from medial to trans Golgi cisternae in baby hamster kidney cells infected with Semliki Forest virus. J Cell Biol. 1983 Mar;96(3):835-50. PMID 6682112
Lowicki, D and Huczyński A (2013). Structure and antimicrobial properties of Monensin A and its derivatives: Summary of the achievements. BioMed Res. Intl. 1–14. doi:10.1155/2013/742149
Nebbia C, Ceppa L, Dacasto M, Carletti M, Nachtmann C (1999) Oxidative metabolism of Monensin in rat liver microsomes and interactions with tiamulin and other chemotherapeutic agents: Evidence for the involvement of cytochrome P-450 3A subfamily. Drug Metab Dispos. 1999 Sep;27(9):1039-44 PMID 10460804
