Moniliformin is a potent, water-soluble mycotoxin produced by several species of Fusarium. Comparative toxicity studies of moniliformin in chicken cell lines revealed no toxicity to chondrocytes and macrophages, but toxicity to splenocytes, cardiac and skeletal myocytes.
Moniliformin is soluble in ethanol, methanol, DMF or DMSO. Good water solubility.
Moniliformin is soluble in ethanol, methanol, DMF or DMSO. Good water solubility.
| Mechanism of Action | Moniliformin selectively inhibits mitochondrial oxidization of pyruvate and α-ketoglutarate, however the mode of action is not yet completely resolved. |
| References | Comparative cytotoxicity of fumonisin B1 and moniliformin in chicken primary cell cultures. Wu W. et al. Mycopathologia 1995, 132, 111 A molecular mechanism for the toxic action of moniliformin, a mycotoxin produced by Fusarium moniliforme. Thiel P. G. Biochem. Pharmacol. 1978, 27, 483. Moniliformin, a metabolite of Fusarium moniliforme NRRL 6322: purification and toxicity. Burmeister H. R. et al. Appl. Environ. Microbiol. 1979, 37, 11. |