SKU: M021  / 
    CAS Number: 64953-12-4

    Moxalactam sodium

    Moxalactam sodium is a third generation cephalosporin antibiotic.

    TOKU-E offers two forms of moxalactam: moxalactam sodium (M021) and moxalactam diammonium salt (M032). Moxalactam sodium is freely soluble in aqueous solution at 50 mg/mL. Moxalactam diammonium salt is sparingly soluble in aqueous solution at 0.751 mg/mL.

    Mechanism of ActionLike β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
    SpectrumMoxalactam targets primarily gram negative bacteria especially those which cause meningitis because of its ability to cross the blood brain barrier.
    Microbiology ApplicationsMoxalactam sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 0.03 µg/mL – 0.12 µg/mL
    • For a complete list of moxalactam MIC values, click here.

    In addition to its use in AST, moxalactam is used as a media supplement in Oxford Listeria agar to select for Listeria monocytogenes in poultry and processed meats.

    Molecular FormulaC20H18N6Na2O9S
    Optical Rotation[α]D22 = -45° (water)
    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

    MICBacteroides disiens| 0.5 - 16|| Bacteroides distasonis| 1 - >128|| Bacteroides fragilis| 0.25 - 256|| Bacteroides melaninogenicus| 0.125 - 16|| Bacteroides oralis | 0.25 - 32|| Bacteroides ovatus| 1 - >128|| Bacteroides putredinis| ≤0.062|| Bacteroides ruminicola | 0.5|| Bacteroides ruminicola subsp. brevis| 0.5 - 128|| Bacteroides thetaiotaomicron| 0.5 - 256|| Bacteroides uniformis| 0.5 - 128|| Bacteroides ureolyticus| 0.125 - 2|| Bacteroides vulgatus| 1 - 16|| Bifidobacterium spp.| 1 - >128|| Brucella| 1 - 16|| Citrobacter diversus| 0.12 - 0.5|| Citrobacter freundii| 0.06 - 8|| Clostridium bifermentans| 0.5 - 8|| Clostridium cadaveris| 0.5 - 8|| Clostridium difficile| 2 - 128|| Clostridium perfringens| 0.5 - >64|| Clostridium ramosum| 8|| Clostridium sordellii| 0.5 - 8|| Clostridium spp.| 0.5 - >64|| Clostridium tertium| 0.5 - 8|| Enterobacter aerogenes| 0.25 - 4|| Enterobacter agglomerans| 0.25 - 4|| Enterobacter cloacae| 0.06 - 4|| Enterobacter gergoviae| 0.25 - 4|| Escherichia coli| 0.015 - 2|| Eubacterium lentum| 1 - >128|| Eubacterium spp.| 0.5 - 4|| Flavobacterium (IIb)| 0.25 - 32|| Fusobacteria| 0.125 - 16|| Fusobacterium mortiferum| 4 - 16|| Fusobacterium necrophorum| 0.125 - 0.25|| Fusobacterium nucleatum| 1 - 4|| Fusobacterium varium| 4 - 16|| Haemophilus influenzae| 0.03 - 0.12|| Helicobacter pylori| 0.05 - 1.56|| Klebsiella pneumonia| 0.015 - 64|| Klebsiella pneumoniae| 0.12 - 0.25|| Lactobacillus spp.| 1 - >128|| Leptotrichia buccalis| 0.5|| Moraxella osloensis | 0.12 - 16|| Morganella morganii| 0.12 - 0.5|| Neisseria gonorrhoeae| ≤0.008 - 0.6|| Neisseria meningitidis| ≤0.008|| Nocardia asteroides| 17.96|| Peptococcus asaccharolyticus| 0.25 - 2|| Peptococcus magnus | 0.125 - 2|| Peptostreptococcus anaerobius| 0.06 - 16|| Peptostreptococcus asaccharolyticus| 0.06 - 16|| Peptostreptococcus magnus| 0.06 - 16|| Peptostreptococcus micros| ≤0.062 - 0.25|| Peptostreptococcus prevotii| ≤0.062 - 2|| Peptostreptococcus tetradius| 0.06 - 16|| Porphyromonas| 0.125 - 64|| Porphyromonas asaccharolytica| 0.125 - 64|| Prevotella bivia| 0.25 - 32|| Prevotella buccae| 0.125 - 64|| Prevotella corporis | 0.5 - 4|| Prevotella disiens| 0.5 - 64|| Prevotella intermedia| 0.5 - 16|| Prevotella melaninogenica| 0.5 - 16|| Prevotella oralis| 0.125 - 64|| Prevotella oris| 0.125 - 64|| Propionibacterium acnes| 1 - 2|| Propionibacterium spp.| 1 - 2|| Proteus mirabilis| 0.25|| Proteus vulgaris| 0.12 - 0.5|| Providencia rettgeri| 0.25 - 0.5|| Providencia stuartii| 0.25 - 0.5|| Pseudomonas acidovorans| 0.12 - 4|| Pseudomonas aeruginosa| 4 - 512|| Pseudomonas cepacia| 2 - 256|| Pseudomonas fluorescens | 0.12 - 256|| Pseudomonas maltophilia| 2 - 256|| Pseudomonas putida| 16 - 256|| Pseudomonas putrefaciens| 0.5 - 2|| Pseudomonas stutzeri| 0.5 - 8|| Ralstonia pickettii| 8|| Serratia marcescens| 0.5 - 512|| Staphylococcus aureus| 3.12 - 256|| Streptococcus faecalis| >256|| Streptococcus pneumoniae| 1|| Streptococcus pyogenes| 1 - 2||