SKU: M045  / 
    CAS Number: 35891-70-4

    Myriocin

    ₹12,077.09 - ₹41,871.32
    Myriocin

    Myriocin is an α-amino fatty acid derived from several genera of fungi, notably Myriococcum, Melanconis and Isaria.

    Myriocin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

    Mechanism of Action Myriocin potently inhibits sphingosine biosynthesis by blocking the first enzyme in the pathway, serine palmitoyltransferase. Myriocin induces apoptosis by depleting cellular sphingolipids, inhibits proliferation of IL-2-dependent mouse cytotoxic cells and is a potent immunosuppressant.

     

    Cancer Applications

    		 Myriocin is known to inhibit sphingolipid synthesis, and was originally investigated for use in cancer treatment inhibiting proliferation without triggering cell death. Sphingolipids are an important component of the cell membrane functioning as structure and part of signaling pathways. Researchers investigated sphingolipids as a target for antifungal activity in addition to myriocin's anticancer activity. They found that Aspergillus fumigatus treated with Myriocin showed usually short, highly-branched hyphae and antifungal activity against planktonic and biofilm-based sessile cells (Perdoni et al, 2015).
    References

    Myriocin, a new antifungal antibiotic from Myriococcum albomyces. Kluepfel D. J. Antibiot. 1972, 25, 109.

    Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Miyake Y. et al. , Biochem. Biophys. Res. Commun. 1995, 211, 396.

    Fungal metabolites. Part 12. Potent immunosuppressant, 14-deoxomyriocin, (2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2-hydroxymethyleicos-6-enoic acid and structure-activity relationships of myriocin derivatives. Fujita T. et al. , J. Biol. Chem. 2005, 280, 10284.

    Perdoni F et al (2015)  Antifungal activity of Myriocin on clinically relevant Aspergillus fumigatus strains producing biofilm. BMC Microbiol. 15:248  PMID 26519193