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Detailed Description
CAS Number: 102130-84-7
Molecular Formula: C36H52O8
Molecular Weight: 612.79
Mechanism of Action: Nemadectin binds to the ion channels that are needed for invertebrate nerve and muscle cell function. This leads to an increase permeability leading to an influx of chloride ions and parasite paralysis.
Storage Conditions: −20°C
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Applications
Spectrum: Nemadectin is broad-spectrum antiparasitic agent effective against nematodes and insects. It has activity against the major canine gastrointestinal helminthes.
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Specifications
Form: Solid
Source: Streptomyces sp.
Purity Level: >95%
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Technical Data
Solubility: Soluble in ethanol, methanol, DMSO and DMF
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References
References:
Carter GT et al (1988) LL-F28249 antibiotic complex: A new family of antiparasitic macrocyclic lactones. Isolation, characterization and structures of LL-F28249 alpha, beta, gamma, lambda. J Antibiot (Tokyo). 41(4):519-529 PMID 337235
Doscher ME, Wood IB, Pankavich JA, Ricks CA (1989) Efficacy of Nemadectin, a new broad-spectrum endectocide, against natural infections of canine gastrointestinal helminths. Vet Parasitol. 34(3):255-259 PMID 2617829
Ling-Yu Yang L et al (2013) New nemadectin congeners with acaricidal and nematocidal activity from Streptomyces microflavus neau3 Y-3, Bioorg. Med. Chem. Lett. 23 (20):5710-5713
Nemadectin is a natural substance with broad-spectrum endectocidal, nematicidal and insecticidal activity. It is a macrocyclic lactone that is structurally similar to milbemycin and avermectin antibiotics, differing by the unsaturated side-chain extending from the 6,6-spiroketal core. This antiparasitic agent can be used as a starting material for the production of Moxidectin.
CAS Number: 102130-84-7
Molecular Formula: C36H52O8
Molecular Weight: 612.79
Mechanism of Action: Nemadectin binds to the ion channels that are needed for invertebrate nerve and muscle cell function. This leads to an increase permeability leading to an influx of chloride ions and parasite paralysis.
Storage Conditions: −20°C
Spectrum: Nemadectin is broad-spectrum antiparasitic agent effective against nematodes and insects. It has activity against the major canine gastrointestinal helminthes.
Form: Solid
Source: Streptomyces sp.
Purity Level: >95%
Solubility: Soluble in ethanol, methanol, DMSO and DMF
References:
Carter GT et al (1988) LL-F28249 antibiotic complex: A new family of antiparasitic macrocyclic lactones. Isolation, characterization and structures of LL-F28249 alpha, beta, gamma, lambda. J Antibiot (Tokyo). 41(4):519-529 PMID 337235
Doscher ME, Wood IB, Pankavich JA, Ricks CA (1989) Efficacy of Nemadectin, a new broad-spectrum endectocide, against natural infections of canine gastrointestinal helminths. Vet Parasitol. 34(3):255-259 PMID 2617829
Ling-Yu Yang L et al (2013) New nemadectin congeners with acaricidal and nematocidal activity from Streptomyces microflavus neau3 Y-3, Bioorg. Med. Chem. Lett. 23 (20):5710-5713