Neosartoricin B was produced biosynthetically in 2013 by Tang and colleagues from UCLA USA by selecting the gene cluster for neosartoricin that is homologous to a conserved cluster among dermatophytes of the Trichophyton and Arthroderma genera. When integrated into the model Aspergillus nidulans host, a structurally related compound neosartoricin B was formed, suggesting a possible role of this compound in the pathogenesis of these strains. Neosartoricin B is the O-deacetyl analogue of neosartoricin A, an immunosuppressive agent.
Chooi Y et al (2013) Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi. Org. Lett. 15:780
Yin W et al (2013) Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans. ACS Synth. Biol. 2:629