Niclosamide anhydrous

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Detailed Description

CAS Number: 50-65-7

Molecular Formula: C₁₃H₈Cl₂N₂O₄

Molecular Weight: 327.12

Mechanism of Action: Like other salicylanilides, niclosamide translocates hydrogen into the inner membrane of the mitochondria, uncoupling the oxidative phosphorylation from the electron transport and inhibiting the creation of ATP.

Storage Conditions: ≤30°C
References

References: Pan, J.-X., Ding, K., & Wang, C.-Y. (2012). Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells. Chinese Journal of Cancer, 31(4), 178–184. http://doi.org/10.5732/cjc.011.10290

Niclosamide is commonly known as an antihelminthic drug used in the treatment of tapeworms. It has also been used as a molluscicide in water treatment, and more recently there are several reports of niclosamide showing anticancer activity. TOKU-E Company offers two forms of niclosamide: Niclosamide anhydrous (N048) and niclosamide monohydrate (N051).

Niclosamide anhydrous is practically insoluble in water. It is sparingly soluble in ethanol, chloroform and ether.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

CAS Number: 50-65-7

Molecular Formula: C₁₃H₈Cl₂N₂O₄

Molecular Weight: 327.12

Mechanism of Action: Like other salicylanilides, niclosamide translocates hydrogen into the inner membrane of the mitochondria, uncoupling the oxidative phosphorylation from the electron transport and inhibiting the creation of ATP.

Storage Conditions: ≤30°C

References: Pan, J.-X., Ding, K., & Wang, C.-Y. (2012). Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells. Chinese Journal of Cancer, 31(4), 178–184. http://doi.org/10.5732/cjc.011.10290