Niclosamide is commonly known as an antihelminthic drug used in the treatment of tapeworms. It has also been used as a molluscicide in water treatment, and more recently there are several reports of niclosamide showing anticancer activity. TOKU-E Company offers two forms of niclosamide: Niclosamide anhydrous (N048) and niclosamide monohydrate (N051).
Niclosamide anhydrous is practically insoluble in water. It is sparingly soluble in ethanol, chloroform and ether.
This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.
Niclosamide anhydrous is practically insoluble in water. It is sparingly soluble in ethanol, chloroform and ether.
This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.
| Mechanism of Action | Like other salicylanilides, niclosamide translocates hydrogen into the inner membrane of the mitochondria, uncoupling the oxidative phosphorylation from the electron transport and inhibiting the creation of ATP. |
| Molecular Formula | C13H8Cl2N2O4 |
| References | Pan, J.-X., Ding, K., & Wang, C.-Y. (2012). Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells. Chinese Journal of Cancer, 31(4), 178–184. http://doi.org/10.5732/cjc.011.10290 |
