SKU: N081  / 
    CAS Number: 59456-70-1

    Nikkomycin Z

    $150.50 - $527.00

    Nikkomycin Z is a nucleoside-type antibiotic isolated from Steptomyces tendae. Nikkomycin Z has potent narrow spectrum activity against some fungi, including Rhizopus cirdinans, Colletrotrichum trifolii and Botrytis cinerea (MIC 1, 5 and 5 µg/mL) and Coccidioides species, entering clinical development for the treatment of coccidioidomycosis. Nikkomycin Z inhibits chitin synthesis. Nikkomycin Z in combination with caspofungin or micafungin is synergistic against Candida albicans and Candida parapsilosis biofilms. Nikkomycin A is active against Histoplasma capsulatum in vitro and in vivo.

    Molecular Formula  C20H25N5O10
    References

    Dahn et al (1976)  Stoffwechselprodukte von mikroorganismen 154. Mitteilung. Nikkomycin, ein neuer hemmstoff der chitinsynthese bei pilzen. Arch. Microbiol. 107:143

    Ki RK and Rinaldi MG (1999)  In vitro antifungal activity on nikkomycin Z in combination with fluconazole or itraconazole. Antimicrob Agents Chemother. 43: 1401

    Kovacs R et al (2019)  Synergistic effect of nikkomycin Z with caspofungin and micafungin against Candida albicans and Candida parapsilosis biofilms. Lett. Appl. Microbiol. 69:271