Nikkomycin Z is a nucleoside-type antibiotic isolated from Steptomyces tendae. Nikkomycin Z has potent narrow spectrum activity against some fungi, including Rhizopus cirdinans, Colletrotrichum trifolii and Botrytis cinerea (MIC 1, 5 and 5 µg/mL) and Coccidioides species, entering clinical development for the treatment of coccidioidomycosis. Nikkomycin Z inhibits chitin synthesis. Nikkomycin Z in combination with caspofungin or micafungin is synergistic against Candida albicans and Candida parapsilosis biofilms. Nikkomycin A is active against Histoplasma capsulatum in vitro and in vivo.
Molecular Formula | C20H25N5O10 |
References |
Dahn et al (1976) Stoffwechselprodukte von mikroorganismen 154. Mitteilung. Nikkomycin, ein neuer hemmstoff der chitinsynthese bei pilzen. Arch. Microbiol. 107:143 Ki RK and Rinaldi MG (1999) In vitro antifungal activity on nikkomycin Z in combination with fluconazole or itraconazole. Antimicrob Agents Chemother. 43: 1401 Kovacs R et al (2019) Synergistic effect of nikkomycin Z with caspofungin and micafungin against Candida albicans and Candida parapsilosis biofilms. Lett. Appl. Microbiol. 69:271 |