Nogalamycin is an unusual anthracycline bacterial metabolite produced by Streptomyces nogalater var. nogalater reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides: the neutral monosaccharide is attached to the D ring, while the basic saccharide is attached to the phenolic group on the A ring. Nogalamycin is a potent antibacterial and antitumor agent.
Nogalamycin is soluble in ethanol, methanol, DMF or DMSO.
| Mechanism of Action |
Nogalamycin is a DNA intercalator. It interacts with topoisomerase I, thereby inhibiting DNA replication and repair and RNA and protein synthesis. |
| Spectrum |
Nogalamycin has activity against Gram-positive bacteria. |
| References |
Bhuyan BK et al (1965) Antibiotic Nogalamycin and method of producing. US Patent 3,183,157 Bhuyan BK, Smith CG s(1975). Nogalamycin. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and immunosuppressive agents. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 2. Springer, Berlin, Heidelberg. |