Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. Nonactin has been purified to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium.
Nonactin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Nonactin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
| References | Uber Untersuchungen, welche zur Bestimmung der Konfiguration der Nonactinsaure und der Homononactinsaure ausgefiihrt wurden, werden wir in einer spateren Mitteilung berichten. Dominguez J. et al. Helv. Chim. Acta 1962, 45, 129. Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Graven S. N. et al. Biochemistry, 1966, 5, 1735. |