SKU: O044  / 
    CAS Number: 1198574-97-8

    Oxozeaenol, (5E)-7-

    $185.22 - $648.27

    (5E)-7-Oxozeaenol ("iso-LL Z1640-2") is a resorcylic acid lactone belonging to the Zearalenone class, recognised as a minor metabolite of the fungus, Drechslera portulacae. (5E)-7-Oxozeaenol was rediscovered as a major analog of a resorcylic acid lactone complex from a Phoma-related species by Pierce and colleagues in 2011. (5E)-7-Oxozeaenol is the double bond isomer of LL Z1640-2 ((5Z)-7-oxozeaenol), a selective TAK 1 inhibitor. (5E)-7-Oxozeaenol exhibits moderate anti-tumor activity and NF-KB inhibitory activity but is otherwise unexplored.

    Molecular Formula  C19H22O
    References

    Ayers S et al (2011)  Resorcylic acid lactones with cytotoxic and NF-KB inhibitory activities and their structure-activity relationships. J. Nat. Prod.74:1126

    Sugawara F et al (1992)  Zearalenone derivatives produced by the fungus Drechslera portulacae. Phytochem. 31:1987