SKU: O028  / 
    CAS Number: 141196-69-2

    7-Oxostaurosporine

    $277.35 - $970.71
    7-Oxostaurosporine is the oxidised and highly fluorescent analogue of UCN-01 and UCN-02. 7-Oxostaurosporine is a potent inhibitor of protein kinase C and formation of cellular blebs induced by phorbols. 7-Oxostaurosporine possesses comparable activity against tumor cells lines to UCN-01. Despite its close relationship to UCN-01 and staurosporine, limited access to the metabolite has restricted a more complete investigation of its properties.

    7-Oxostaurosporine is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
    Mechanism of Action7-Oxostaurosporine inhibits the cell cycle at the G2 stage with the accumulation of 4C DNA cells
    Molecular FormulaC28H24N4O4
    DocumentsA new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I Taxonomy and biological activity. Osada, H. et al. , J. Antibiot. 1992, 45, 189.

    A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II Fermentation, Isolation, Physico-chemical properties and structure. Koshino H. et al. , J. Antibiot. 1992, 45, 195.