SKU: P150  / 
    CAS Number: 23668-11-3

    Pactamycin

    $269.09 - $942.28

    Pactamycin (syn: Pactacin) is a unique type of highly-substituted aminocyclitol produced by Streptomyces sp. which is a potent inhibitor of translation in eukaryotes, bacteria and archaea, active against Gram-positive and Gram-negative bacteria.  Pactamycin was patented by Upjohn Inc. in 1967 as an antiviral. Pactamycin binds to the 30S ribosomal subunit at a site distinct from tetracycline and hygromycin B, promoting structural changes that prevent the tRNA from binding. Pactamycin also exhibits antineoplastic and antimalarial properties. Although its use was limited by toxicity, some semisynthetic analogs are less toxic.

    Molecular Formula  C28H38N4O8
    References

    Bhuyan BK et al (1962)  Pactamycin, a new antitumor antibiotic. I. Discovery and biological properties.Antimicrob Agents Chemother. 184

    Brodersen DE et al (2000)  The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit Cell 103:1143

    Hurley TR et al PD 113,618 and PD 118,309, (1986)  New pactamycin analogs. J Antibiot. 39: 1086

    Mankin AS (1997) Pactamycin resistance mutations in functional site of 16 S mRNA J Mol Biol. 274:8

    Smith CG (1967)  Controlling viral activity with pactamycin US 3304231 19670214