Paromomycin Sulfate, USP is the sulfate salt of Paromomycin, an aminoglycoside antibacterial and antiparasitic compound.
It is soluble in water.
| Mechanism of Action | Like many aminoglycosides, paromomycin targets the 16S rRNA of the 30S ribosomal subunit and prevents translocation and misreading of mRNA by stabilizing aminoacyl-tRNA in the acceptor (“A”) site. |
| Spectrum |
Paromomycin is a broad spectrum antibiotic targeting a wide range of Gram-positive and Gram-negative bacteria including Escherichia coli and Staphylococcus species. |
| Impurity Profile |
LD50 in mice (mg/kg): ≈15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli). |
| Molecular Formula | C23H45N5O14 · H2SO4 |
| References |
Davidson, R. N., and et al. "Paromomycin." Transactions of the Royal Society of Tropical Medicine and Hygiene 103.7 (2009): 653-60. www.ncbi.gov. Web. 6 Sept. 2012. Puglisi, Joseph D., and et al. "Paromomycin Binding Induces a Local Conformational Change in the A-site of 16 S RRNA." Journal of Molecular Biology 277.2 (1998): 335-45 www.ncbi.gov. Web. 6 Sept. 2012. |
| MIC | Escherichia coli | 4 － 5.5|| Lactobacillus acidophilus| 62.5 － 250|| Lactobacillus bulgaricus| 125 － 500|| Lactobacillus casei | 125 － 250|| Lactobacillus lactis| ≥250|| Lactobacillus paracasei| ≥125|| Lactobacillus plantarum | 125 － 250|| Lactobacillus rhamnosus| 250 － 500|| Mycobacterium tuberculosis| ≥2.5|| Pseudomonas aeruginosa| ≥16|| Staphylococcus aureus (ATCC 25923)| ≥0.5|| |
