SKU: P002  / 
    CAS Number: 1263-89-4

    Paromomycin sulfate

    S/.899.10 - S/.2,988.90
    Paromomycin sulfate

    Paromomycin sulfate is a freely soluble (50 mg/mL) aminoglycoside antibacterial and antiparasitic drug.

    Mechanism of ActionLike many aminoglycosides, paromomycin targets the 16S rRNA of the 30S ribosomal subunit and prevents translocation and misreading of mRNA by stabilizing aminoacyl-tRNA in the acceptor (“A”) site.
    Spectrum

    Paromomycin is a broad spectrum antibiotic targeting a wide range of gram positive and gram negative bacteria including Escherichia coli and Staphylococcus species.

    Impurity Profile

    LD50 in mice (mg/kg): ≈15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli).

    Molecular FormulaC23H45N5O14 · H2SO4
    Impurity Profile

    LD50 in mice (mg/kg): ≈15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli).

    References

    Davidson, R. N., and et al. "Paromomycin." Transactions of the Royal Society of Tropical Medicine and Hygiene 103.7 (2009): 653-60. www.ncbi.gov. Web. 6 Sept. 2012.

    Puglisi, Joseph D., and et al. "Paromomycin Binding Induces a Local Conformational Change in the A-site of 16 S RRNA." Journal of Molecular Biology 277.2 (1998): 335-45 www.ncbi.gov. Web. 6 Sept. 2012.

    MICEscherichia coli | 4 － 5.5|| Lactobacillus acidophilus| 62.5 － 250|| Lactobacillus bulgaricus| 125 － 500|| Lactobacillus casei | 125 － 250|| Lactobacillus lactis| ≥250|| Lactobacillus paracasei| ≥125|| Lactobacillus plantarum | 125 － 250|| Lactobacillus rhamnosus| 250 － 500|| Mycobacterium tuberculosis| ≥2.5|| Pseudomonas aeruginosa| ≥16|| Staphylococcus aureus (ATCC 25923)| ≥0.5||