Paxilline is a tremorgenic mycotoxin isolated from species of Penicillium, Acremonium and Emericella.
Paxilline is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Paxilline is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
| Mechanism of Action | Paxilline selectively blocks high-conductance Ca2+-activated potassium channels and inhibits binding to the cerebellar inositol 1,4,5-triphosphate (InsP(3)) receptor. |
| References | A new tremorgenic metabolite from Penicillium paxilli. Cole R. J. et al. Can. J. Microbiol. 1974, 20, 1159. Characterization of high affinity binding sites for charybdotoxin in synaptic plasma membranes from rat brain. Evidence for a direct association with an inactivating, voltage-dependent, potassium channel. Vazquez J. et al. J. Biol. Chem. 1990, 265, 1556. Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Sanchez M. & McManus O. B. Neuropharmacology 1996, 35, 963. |