Pentostatin is a potent antitumor antibiotic isolated from a Streptomyces species. Pentostatin is a potent inhibitor of adenine deaminase and has been used therapeutically as an antitumor agent.
Pentostatin is soluble in ethanol, methanol, DMF or DMSO. Good water solubility.
Pentostatin is soluble in ethanol, methanol, DMF or DMSO. Good water solubility.
| Mechanism of Action | Pentostatin is a potent inhibitor of adenine deaminase (ADA) and has been used therapeutically as an antitumor agent. |
| Molecular Formula | C11H16N4O4 |
| References | A novel adenosine and ara-A deaminase inhibitor, (R)-3-(2-deoxy-b-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol. Woo P. W. K. et al. J. Het. Chem. 1974, 11, 641. Pentostatin: future directions. Klohs W. D. & Kraker A. J. Pharmacol Rev 1992, 44, 459. |