SKU: P155  / 
    CAS Number: 102-07-8

    Pepstatin A

    1,447,095.00Rp - 5,011,890.00Rp

    Pepstatin A, a pentapeptide isolated from Streptomyces sp. is a strong inhibitor of aspartyl proteases such as pepsin, cathepsin D, and renin. Pepstatin is active against HIV-1 and Plasmodium falciparum. HIV-infected H9 cells incubated with pepstatin A at 10-4M for 2, 4 or 10 days had significantly reduced HIV core antigen (p24) and no infectious HIV. Pepstatin A exerts its antimalarial activity via P. falciparum plasmepsin II binding sites. Pepstatin A suppresses NF-​κB ligand (RANKL)​-​induced osteoclast differentiation and decreases the expression of nuclear factor of activated T cells c1 (NFATc1)​, suggesting that suppresses the differentiation of osteoclasts through the blockade of ERK signaling and the inhibition of NFATc1 expression.

    Molecular Formula  C34H63N5O9
    References

    Andrews KT et al (2006)  Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria.  Antimicrob. Agents Chemother. 50:639

    Umezawa H et al (1970)  Pepstatin, a new pepsin inhibitor produced by Actinomycetes.  J Antibiot. XXIII, 259

    von der Helm K et al (1989)  Inhibition of HIV replication in cell culture by the specific aspartic protease inhibitor pepstatin A. FEBS Lett. 247:349