Hecogenin Acetate is a steroidal saponin first published in 1943 by Marker and colleagues at Penn State University, USA and isolated from plants of the Agave genus. Hecogenin Acetate induces cell cycle arrest and senescence, and modulates ERK1/2 phosphorylation and MMP-2 production. Hecogenin Acetate has nociceptive activity mediated by opioid receptors and endogenous analgesic mechanisms.
Gama KB et al (2013) Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate. J. Nat. Prod. 76 (4):559
Gasparotto J et al (2014) Hecogenin acetate inhibits reactive oxygen species production and induces cell cycle arrest and senescence in the A549 human lung cancer cell line. Anticancer Agents Med. Chem. 14:1128
Marker RE et al (1943) Sterols. CLVII. Sapogenins. 69. Isolation and structures of thirteen new steroidal sapogenins. New sources for known sapogenins. J. Am.Chem. Soc. 165:1199