Phenylpyropene A is a meroterpenoid isolated from Penicillium griseofulvum by researchers at the Korean Research Institute of Bioscience and Biotechnology in 2002. Phenylpyropene A inhibits conversion of cholesterol to cholesteryl esters via inhibition of acyl-CoA:cholesterol acyltransferase (ACAT). Phenylpyropene A also inhibits diacylglycerol acyltransferase (DGAT), the terminal step in triglyceride synthesis and essential for intestinal absorption and adipose tissue formation. Phenylpyropene A has significant cytotoxicity against Sf9 cells from the army worm, Spodoptera frugiperda.
| Molecular Formula | C32H38O10 |
| References | Kwon OE et al (2002) Phenylpyropene A and B, new inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium griseofulvum F1959. J. Antibiot. 55:1004 Lee SW et al (1785) Inhibition of diacylglycerol acyltransferase by phenylpyropenes produced by Penicillim griseofulvum F1959. J. Microbiol. Biotech. 18:1785 Lan WJ et al (2016) Five new cytotoxic metabolites from the marine fungus Neosartorya pseudofischer. Marine Drugs 14:18 |