SKU: P149  / 
    CAS Number: 189564-20-3

    Phenylpyropene A

    $216.09 - $756.32

    Phenylpyropene A is a meroterpenoid isolated from Penicillium griseofulvum by researchers at the Korean Research Institute of Bioscience and Biotechnology in 2002. Phenylpyropene A inhibits conversion of cholesterol to cholesteryl esters via inhibition of acyl-CoA:cholesterol acyltransferase (ACAT). Phenylpyropene A also inhibits diacylglycerol acyltransferase (DGAT), the terminal step in triglyceride synthesis and essential for intestinal absorption and adipose tissue formation. Phenylpyropene A has significant cytotoxicity against Sf9 cells from the army worm, Spodoptera frugiperda.

    Molecular Formula  C32H38O10 
    References

    Kwon OE et al (2002)  Phenylpyropene A and B, new inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium griseofulvum F1959. J. Antibiot. 55:1004

    Lee SW et al (1785) Inhibition of diacylglycerol acyltransferase by phenylpyropenes produced by Penicillim griseofulvum F1959. J. Microbiol. Biotech. 18:1785

    Lan WJ et al (2016) Five new cytotoxic metabolites from the marine fungus Neosartorya pseudofischer.  Marine Drugs 14:18