Pitavastatin Calcium is the calcium salt of Pitavastatin, a compound that inhibits cholesterol synthesis and displays cardioprotective properties. Pitavastatin may be usefully combined with zoledronic acid in cancer therapy.
|Mechanism of Action||Pitavastatin in the enzyme that catalyzes the first step in cholesterol synthesis known as HMG-CoA reductase.|
Recent lab results have suggested that Pitavastatin is superior to other statins for use in oncology because it is the only statin that is both lipophilic, and has a suitably long half-life . Pitavastatin was found to inhibit the growth of ovarian cancer cell cultures. Combinations with zoledronic acid displayed additive or synergistic effects in 10 of 11 cell lines tested (Abdullah et al, 2017).
|Molecular Formula|| |
C50H46F2N2O8 • Ca
Abdullah, MI et al. (2017) Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells. Scientific Rep. 8090
Saka M et al. (2006) Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure. J. Cardiovasc. Pharmacol. 47:770-779