Plumbagin is a yellow-orange pigment isolated from Plumbagin and other plant species. Research into Plumbagin dates back to the early 1800s, with its synthesis reported in 1936. Plumbagin has a broad biological activity, including bactericidal, fungicidal, tuberculostatic, larvicidal, nematocidal, ichthyotoxic, anti-inflammatory and seed germination inhibitory activity, as well as weak insect antifeedant activity. Pumbagin’s activity is attributed to its effects on multiple signaling and apoptotic pathways, and its ability to undergo redox cycling property generating ROS. Plumbagin induces quinone reductase and glutathione transferase and is a potent inhibitor of NF- κB.
| Molecular Formula | C11H8O3 |
| References |
Fieser LF and Dunn JT (1936) Synthesis of Plumbagin. J Am Chem Soc. 58:572 Higa M et al (1998) Bioactive naphthoquinone derivatives from Diospyros maritima BLUME. Chem Pharm Bull. 46:1189 Munday R and Munday CM (2000) Induction of quinone reductase and glutathione transferase in rat tissues by juglone and Plumbagin. Planta Med 66: 399. Padhye S et al (2012) Perspectives on medicinal properties of Plumbagin and its analogs. Med Res Rev. 32:1131 |