Pseurotin A is a fungal metabolite with an unusual hetero-spirocyclic ring system. It has potent neuritogenic activity in PC12 phaechromocytoma cells, a useful model for adrenergic neuronal differentiation. Pseurotin A also exhibits chitinase inhibition and acts synergistically with azole antifungal agents.
Pseurotin A is soluble in ethanol, methanol, DMF and DMSO.
Pseurotin A is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Pseurotin A induces multipolar and branching neurites comparable to β-NGF, an endogenous neurotrophic factor. |
| References | Novel neuritogenic activities of pseurotin A and penicillic acid. Komagata D. et al. J Antibiot. 1996, 49, 958. Synerazol, a new antifungal antibiotic. Ando O. et al. J Antibiot. 1991, 44, 382. Pseurotin, a new metabolite of Pseudeurotium ovalis Stolk having an unusual hetero-spirocyclic system. Bloch P. et al. Helv. Chim. Acta 1976, 59, 133. |