SKU: P162  / 
    CAS Number: 5739-85-5

    Pyrenophorin

    NT$7,248.83 - NT$25,864.61

    Pyrenophorin, the diketone analogue of pyrenophorol, was first reported as a metabolite of the oat pathogen Pyrenophora avenae showing cytostatic properties. Pyrenophorin is a simple macrocyclic dilactone with phytotoxic and antifungal activity. Pyrenophorin inhibits seed germination but once the seed is germinated, pyrenophlorin enhances root development but causes abnormal chlorophyll retention in leaf sections. Pyrenophorin is more potent but less selective than pyrenophorol. Its mechanism of action involves electron misdirection and generation of reactive oxygen species. Pyrenophorin is a potent antifungal, significantly reducing the growth of M. violaceum and S. cerevisiae at 5 μM.

    Molecular Formula  C16H20O6
    References

    Kastanias MA and Chrysayi-Tokousbalides M. (2005)  Bioactivity of the fungal metabolite (8R,16R)-(-)-pyrenophorin on graminaceous plants.  J. Agric Food Chem. 53:5943

    Lerario P and Graniti A (1985)  Phytotoxic activity of pyrenophorin and its production in cultures of Pyrenophora avenae Ito et Kurib. Phytopathologia Mediterranea 24:280

    McMullin DR et al (2015)  Antifungal sesquiterpenoids and macrolides from an endophytic Lophodermium species of Pinus strobus. Phytochem Lett. 14:148

    Nozoe S et al (1965)  Structure of pyrenophorin. Nozoe S. et al. Tetrahedron Lett. 51:4675