Radicinol is a mycotoxin isolated from Curvularia lunata (syn. Cochliobolus lunata) by researchers at Nagoya University, Japan in 1977. Subsequently, Radicinol has been found as a secondary metabolite in a diverse range of plant pathogenic fungi. Radicinol is herbicidal and is the likely phytotoxic component in the pathogenicity of the fungus. Radicinol induces apoptosis via modulation of p53 and BCL-2, increasing caspase-3 expression in cancer cells.
| Molecular Formula | C12H14O5 |
| References | Nukina N and Marumo S (1962) Radicinol, a new metabolite of Cochliobolus lunata, and absolute stereochemistry of radicinin. Tetrahed. Lett. 37:3271 Giridharan P. et al (2017) Antiproliferative activity of hamigerone and radicinol isolated from Bipolaris papendorfii. BioMed. Res. Int 890904/1. Solfrizzo M (date) Toxigenic profile of Alternaria alternata and Alternaria radicina occurring on umbelliferous plants. Food Addit. Contam. 4:302 |