Resistoflavine is a rare, boat-shaped, pentacyclic polyketide isolated from several species of Streptomyces, often co-produced with resistomycin. Resistoflavine exhibits weak antibacterial activity against Gram positive and Gram negative bacteria and exhibits potent cytotoxic activity against tumor cell lines in vitro. Resistoflavine inhibits growth, and nucleic acid and protein synthesis in Bacillus subtilis.
Resistoflavine is soluble in DMF and DMSO and is moderately soluble in methanol or ethanol.
Resistoflavine is soluble in DMF and DMSO and is moderately soluble in methanol or ethanol.
| References | Zur konstitution des antibiotikums resistoflavin. Eckardt K. et al. , Tetrahedron 1970, 26, 5875. Effect of the antibiotics resistomycin and resistoflavin on growth, nucleic acid and protein synthesis in Bacillus subtilis. Haupt I. & Eckardt K., Z Allg Mikrobiol. 1972, 12, 575. Resistoflavine, cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN1/7. Gorajana A. et al. , Microbiol Res. 2007, 162, 322. |